SA Journal of Diabetes & Vascular Disease: Vol 4, Issue 3, September 2007

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SAJDVD: VOLUME 4, ISSUE 3, SEPTEMBER 2007

Title: Combination therapy for diabetic dyslipidaemia - the jury is still out : editorial
Authors: Raal, F.J.
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 112-113
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Title: Rational therapy of mixed dyslipidaemia in a patient with diabete : achieving best practice
Authors: Reasner, Charles
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 115-120
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Abstract: Diabetic dyslipidaemia refers to the triad of elevated levels of triglycerides and small, dense LDL-C particles and low levels of HDL-C. These lipid abnormalities are largely responsible for the increased risk of cardiovascular complications in patients with diabetes. This case study outlines a rational approach to the treatment of each of these lipid abnormalities and emphasises the importance of both lowering the LDL-C and raising the HDL-C in highrisk individuals. Combination drug therapy will often be necessary to achieve treatment goals in these patients.
Title: Why we need a new model for diabetes care : achieving best practice
Authors: Matthews, David R.
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 121-122
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Abstract: MODEL (Management Of Diabetes for ExceLlence) is a group of healthcare professionals calling for a higher ideal of diabetes care in England and Wales. Its report, published in May 2007, finds that while diabetes care is good in many aspects and regions, there are still significant gaps and shortcomings, particularly in the care of children and young people. The scale of growth of diabetes and its growing impact on healthcare costs indicate that a much more forward-looking approach is needed if the NHS is to meet future demands.
Title: Comment : a South African perspective on MODEL (Management Of Diabetes for ExceLlence) : achieving best practice
Authors: Levitt, Naomi S.
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 123
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Title: Drug treatments for obesity : where are we heading and how do we get there? : achieving best practice
Authors: Sonnenberg, Gabriele E.; Matfin, Glenn; Reinhardt, Rickey R.
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 124-130
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Abstract: Obesity has reached epidemic proportions with an estimated 1.7 billion people worldwide classified as either overweight or obese. Obesity is associated with multiple co-morbidities (often clustered as the metabolic syndrome), and can result in decreased life expectancy, with enormous costs to society.
Even modest weight loss has been demonstrated to exhibit beneficial effects on the co-morbidities of obesity. While reduced caloric intake and increased physical activity, combined with behavioural modification, appears to be the most rational approach to weight reduction, it only offers short-lived success. For severely obese individuals, bariatric surgery has become an increasingly preferred option resulting in dramatic and well-maintained weight reductions followed by significant changes in obesity-related diseases.
Currently, few anti-obesity drugs are approved by regulatory authorities for long-term use (i.e. orlistat, sibutramine and rimonabant). Anti-obesity drug development is an active and dynamic field focusing on two major approaches: 1) inhibiting energy intake by addressing the input into the hypothalamic feeding centre or, 2) attempting to accelerate energy expenditure. Overcoming the hurdles of developing such medications is a daunting task, but it can be anticipated that several drugs in current development might become available within the next decade, and combination therapy of two or more agents could be the future of pharmacological prevention and treatment of obesity.
Title: ADVANCE in the prevention of cardiovascular disease in type 2 diabetics : current topics
Authors: Rayner, Brian
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 131-132
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Abstract: Type 2 diabetes (T2D) and hypertension are comorbid clinical conditions that act synergistically to substantially raise the risk of both micro- and macrovascular complications. Seventy to 80% of type 2 diabetics have hypertension, and overall the chance of a cardiovascular event within 10 years is two to threefold higher than that of each condition alone. It has become central to the treatment of T2D to co-manage diabetes and hypertension through tight glucose and blood pressure (BP) control to prevent both microand macrovascular disease, and reduce cardiovascular events. Yet surprisingly, given the almost epidemic proportions of T2D, we have few evidence-based trials on which to base our clinical guidelines.
Title: Diabetic papillopathy diagnosed on retinal screening in an asymptomatic patient : case report
Authors: Zachariah, Sunil; Sharfi, Osman; Burton, Ben; Nussey, Stephen Spencer; Bano, Gul
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 134-135
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Title: Body mass index (BMI) or waist-hip ratio? : monitoring
Authors: Kirby, Mike
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 137-139
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Title: Update on diabetic complications : drug trends in diabetes
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 140-144
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Title: Batswadi invests in improving patient care with expert input at SEMSDA congress : drug trends in diabetes
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 145-146
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Title: Metabolic syndrome and insulin resistance is strongly associated with lower testosterone levels : drug trends in diabetes
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 146-147
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Title: Successful use of once-daily biphasic insulin aspart 30 with metformin in type 2 diabetes : drug trends in diabetes
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 148
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Title: Changing diabetes - the highroad to diabetes prevention in South Africa : diabetes news
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 150
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Title: Fifty years of metformin, the first option in type 2 diabetes : diabetes news
From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 3, Aug / Sep
Published: 2007
Pages: 152
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