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ISSN 1811-6515
THE SOUTH AFRICAN JOURNAL OF
Diabetes & vascular disease
Corresponding Editor
Dr L Lombard
Netcare, Kuilsrivier Hospital,
Cape Town
Consulting Editors
PROF J-C MBANYA
PROF AJ BRINK
DR F MAHOMED
National Editorial Board
DR A AMOD
Centre for Diabetes, Endocrinology and
Metabolic Diseases, Life Healthcare,
Chatsmed Gardens Hospital, Durban
SR K BECKERT
Diabetes Nurse, Paarl
PROF F BONNICI
Emeritus Professor, Faculty of Health
Sciences, University of Cape Town and
President of Diabetes South Africa
PROF R DELPORT
Department of Family Medicine,
University of Pretoria
DR L DISTILLER
Director of the Centre of Diabetes
and Endocrinology, Houghton,
Johannesburg
DR F MAHOMED
Department of Endocrinology,
Grey’s Hospital, Pietermaritzburg
PROF WF MOLLENTZE
Head of Department of Internal
Medicine, University of the Free State,
Bloemfontein
PROF CD POTGIETER
Specialist Nephrologist, University
of Pretoria and Jakaranda Hospital,
Pretoria
PROF K SLIWA
Associate Professor of Medicine and
Cardiology, Baragwanath Hospital,
University of the Witwatersrand, Johan-
nesburg
PROF YK SEEDAT
Emeritus Professor of Medicine and
Honorary Research Associate,
University of Natal, Durban
International Editorial Board
PROF IW CAMPBELL
Physician, Victoria Hospital, Kircaldy,
Scotland, UK
PROF PJ GRANT
Professor of Medicine and head of
Academic Unit of Molecular Vascular
Medicine, Faculty of Medicine and
Health, University of Leeds; honorary
consultant physician, United Leeds
Teaching Hospitals NHS Trust, UK
PROF J-C MBANYA
Professor of Endocrinology, Faculty of
Medicine and Biomedical Sciences,
University of Yaounde I, Cameroon
and President, International Diabetes
Federation
PROF N POULTER
Professor of Preventive Cardiovascular
Medicine, Imperial College, School of
Medicine, London, UK
DR H PURCELL
Senior Research Fellow in Cardiology,
Royal Brompton National Heart and
Lung Hospital, London, UK
VOLUME 9 NUMBER 1 • MARCH 2012
www.diabetesjournal.co.za
CONTENTS
Editorial
3
New therapies change diabetes practice
L Lombard
Reviews
4
New antithrombotic drugs: a revolution in stroke management
A Bryer
7
Anticoagulation therapy in diabetic patients
PF Wessels
10
DPP-4 inhibitors (gliptins) in the management of type 2 diabetes
L Lombard
14
High lifetime risk of cardiovascular disease in South Africans of mixed
ancestry: findings of the Bellville, South Africa pilot study
G Hardy
Research Articles
16
Impact of vascular complications on serum levels of soluble RAGE and
TNF-α in females with type 2 diabetes
MA Zaki, KM Ahmed
22
Association of serum tumour necrosis factor-α and interleukin-6 with
insulin secretion and insulin resistance in subjects with type 2 diabetes
in a Bangladeshi population
M Hossain, O Faruque, G Kabir, I Khan, D Sikdar, L Ali