Background Image
Table of Contents Table of Contents
Previous Page  26 / 30 Next Page
Information
Show Menu
Previous Page 26 / 30 Next Page
Page Background

62

VOLUME 17 NUMBER 2 • NOVEMBER 2020

Report

SA JOURNAL OF DIABETES & VASCULAR DISEASE

Key learnings

• Insulin resistance and obesity each give rise to the other, potentially

resulting in more severe obesity and T2DM.

• Weight reduction is considered a key therapeutic goal in the treatment of

T2DM, demonstrating numerous beneficial health effects.

• Metabolic surgery is the best treatment option for patients with diabesity,

although most patients can only be managed with combined lifestyle

interventions and antidiabetic medications.

• Of the available antidiabetic medications, GLP-1 RAs are associated with

the greatest weight loss, with variation among individual GLP-1 RAs and in

different patient groups.

• The thiazolidinediones, insulin and sulphonylureas are associated with

weight gain.

• Medications for treatment of other conditions may increase body weight.

References

1. Leitner DR, Fruhbeck G, Yumuk V,

et al

. Obesity and type 2 diabetes. Two diseases

with a need for combined treatment strategies – EASO can lead the way.

Obes

Facts

2017;

10

(5): 483–492.

2. Garcia-Jiminez C, Gutierrez-Salmeron M, Chocarro-Calvo A,

et al

. From obesity

to diabetes and cancer: Epidemiological links and role of therapies.

Br J Cancer

2016;

114

(7): 716–722.

3. Duclos M. Osteoarthritis, obesity and type 2 diabetes: The weight of waist

circumference.

Ann Phys Rehabil Med

2016;

59

(3): 157–160.

4. Apicella M, Campopiano M, Mantuano M,

et al

. COVID-19 in people with

diabetes: Understanding the reasons for worse outcomes.

Lancet Diabetes

Endocrinol

2020 [Epub ahead of print].

5. Igel LI, Saunders KH, Fins JJ. Why weight? An analytic review of obesity

management, diabetes prevention, and cardiovascular risk reduction.

Curr

Atheroscler Rep

2018;

20

(8): 39.

6. Verma S, Hussain ME. Obesity and diabetes: An update.

Diabetes Metab Syndr

2017;

11

(1): 73–79.

7. Lindstrom J, Louheranta A, Mannelin M,

et al

. The Finnish Diabetes Prevention

Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity.

Diabetes Care

2003;

26

(12): 3230–3236.

8. Diabetes Prevention Program Research Group. Reduction in incidence of type 2

diabetes with lifestyle intervention or metformin.

N Engl J Med

2002;

346

(6):

393–403.

9. Wing RR, Lang W, Wadden TA,

et al

. Benefits of modest weight loss in improving

cardiovascular risk factors in overweight and obese individuals with type 2

diabetes.

Diabetes Care

2011;

34

(7): 1481–1486.

10. Look AHEAD Research Group. Long-term effects of a lifestyle intervention on

weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus:

four-year results of the Look AHEAD trial.

Arch Intern Med

2010;

170

(17): 1566–

1575.

11. Rubin RR, Wadden TA, Bahnson JL,

et al

. Impact of intensive lifestyle intervention

on depression and health-related quality of life in type 2 diabetes: The Look

AHEAD Trial.

Diabetes Care

2014;

37

(6): 1544–1553.

12. Foster GD, Borradaile KE, Sanders MH,

et al

. A randomized study on the effect

of weight loss on obstructive sleep apnea among obese patients with type 2

diabetes: the Sleep AHEAD study.

Arch Intern Med

2009;

169

(17): 1619–1626.

13. Boles A, Kandimalla R, Reddy PH. Dynamics of diabetes and obesity:

Epidemiological perspective.

Biochim Biophys Acta Mol Basis Dis

2017;

1863

(5):

1026-1036.

14. Wharton S, Lau DCW, Vallis M,

et al

. Obesity in adults: a clinical practice guideline.

CMAJ 2020; 192: E875–891.

15. Pappachan JM, Fernandez CJ, Chacko EC. Diabesity and antidiabetic drugs.

Mol

Aspects Med

2019;

66

: 3–12.

16. Pi-Sunyer X, Astrup A, Fujioka K,

et al

. A randomized, controlled trial of 3.0 mg

of liraglutide in weight management.

N Engl J Med

2015;

373

(1): 11–22.

17. Dungan KM, Povedano ST, Forst T,

et al

. Once-weekly dulaglutide versus once-

daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6):

a randomised, openlabel, phase 3, non-inferiority trial.

Lancet

2014;

384

(9951):

1349–1357.

18. Dushay J, Mitten EK, Gao C,

et al

. Short-term exenatide treatment leads to

significant weight loss in a subset of obese women without diabetes.

Diabetes

Care

2012;

35

: 4–11.

19. Christou GA, Katsiki N, Blundell J,

et al

. Semaglutide as a promising antiobesity

drug.

Obes Rev

2019;

20

(6): 805–815.

20. Farzi A, Hassan AM, Zenz G,

et al

. Diabesity and mood disorders: Multiple links

through the microbiota-gut-brain axis.

Mol Aspects Med

2019;

66

: 80-93.

21. Jantaratnotai N, Mosikanon K, Lee Y,

et al

. The interface of depression and

obesity.

Obes Res Clin Pract

2017;

11

(1): 1–10.

DYNATOR 10, 20, 40, 80 mg.

Each tablet contains 10, 20, 40, 80 mg atorvastatin respectively. S4

A43/7.5/0167, 0168, 0169, 0170. NAM NS2 13/7.5/0111, 0112, 0113, 0114. For full prescribing information,

refer to the professional information approved by SAHPRA, 02 June 2017.

1)

Klug E,

et al.

South African

dyslipidaemia guideline consensus statement.

S Afr Med J

. 2012;102:177-188.

DRB625/10/2019.

CUSTOMER CARE LINE

0860 PHARMA (742 762) / +27 21 707 7000

www.pharmadynamics.co.za

“Intensive management

of dyslipidaemia in

South Africa will

significantly reduce the

cardiovascular disease

health burden”

1