SA JOURNAL OF DIABETES & VASCULAR DISEASE
RESEARCH ARTICLE
VOLUME 7 NUMBER 4 • NOVEMBER 2010
153
evolution, age of onset, and the degree of
β
-cell destruction.
32
HLA-
A24, as defined serologically, has been reported to be associated
with disease as well as with age of onset and A*2402 was the
only allele observed within the A*24 allelic group, which consisted
of several in the Filipino population. In another study, the C locus
was the only class I locus that showed different allele frequency
distribution among patients and controls.
33
The association of
C*0102 with type 1 diabetes (OR
=
2.6;
p
=
0.05) was not simply
attributable to the linkage disequilibrium (LD) with the high-risk
DR-DQ haplotype. Similarly, the negative association of C*0102
does not reflect LD with the protective DR-DQ haplotypes.
29
A study of an Egyptian population showed that patients with
T1D had a significant increase in frequency of HLA-A2, HLA-B8
and HLA-B15. On the other hand, HLA-A3, HLA-B5 and HLA-B7
have been found to be significantly decreased in patients with T1D,
therefore suggesting that these alleles may confer a protective
effect from acquiring T1D.
34
Conclusion
The development of T1D in the Algerian population was strongly
dependent on the presence of the susceptibility HLA class II -DR3,
-DR4, -DQ2 and -DQ8 antigens in three patient groups. The
T1D-associated HLA-DR3/DR4 antigen combination found to be
significant in Caucasian populations was also significantly increased
in the Algerian T1D patients.
The HLA class II data in the three patients groups were
similar and the autoimmune disease childhood T1D is not rare
in our population. We are planning additional work in order to
determinate the allele distribution for both HLA class I and II regions
in our three patient groups.
Acknowledgments
The authors acknowledge the invaluable contributions of Prof D
Latinne and Dr T Gervais of Laboratoire d’Immunohématologie
UCL Clinique Saint Luc Bruxelles (Belgique). We also thank the
patients and families for their participation.
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