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SA JOURNAL OF DIABETES & VASCULAR DISEASE
RESEARCH ARTICLE
Daniel Binette: new managing
director, Lilly South Africa
D
aniel Binette has been
appointed
managing
director of Lilly South Africa.
His career at Lilly Canada spans
17 years and he is known as a
strategic and dynamic results-
orientated leader with multiple
launch experiences (Forteo,
Cymbalta Pain, Cialis BPH
and Axiron). Most recently,
Daniel was next-generation
customer engagement leader
where he provided a strong
understanding of external
trends and potential innovative
solutions to address customer
needs. He is described as
a driven, personable and
innovative leader. He gradu-
ated from Laval University in Quebec, Canada where he holds
an undergrad in Business Science and an MBA.
VOLUME 14 NUMBER 2 • DECEMBER 2017
73
30. Agil A, El-Hammadi M, Jimenez-Aranda A,
et al
. Melatonin reduces hepatic
mitochondrial dysfunction in diabetic obese rats.
J Pineal Res
2015;
59
: 70–79.
31. Ghosh G, De K, Maity S,
et al
. Melatonin protects against oxidative damage and
restores expression of GLUT4 gene in the hyperthyroid rat heart.
J Pineal Res
2007;
42
: 71–82.
32. Nduhirabandi F, du Toit EF, Blackhurst D, Marais D, Lochner A. Chronic melatonin
consumption prevents obesity-related metabolic abnormalities and protects the
heart against myocardial ischemia and reperfusion injury in a prediabetic model
of diet-induced obesity.
J Pineal Res
2011;
50
: 171–182.
33. Nduhirabandi F, Huisamen B, Strijdom H, Blackhurst D, Lochner A. Short-term
melatonin consumption protects the heart of obese rats independent of body
weight change and visceral adiposity.
J Pineal Res
2014;
57
: 317–332.
34. Huisamen B, Donthi RV, Lochner A. Insulin in combination with vanadate
stimulates glucose transport in isolated cardiomyocytes from obese zucker rats.
Cardiovasc Drugs Ther
2001;
15
: 445–452.
35. Huisamen B, Dietrich D, Bezuidenhout N,
et al
. Early cardiovascular changes
occurring in diet-induced, obese insulin-resistant rats.
Mol Cell Biochem
2012;
368
: 37–45.
36. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the
folin phenol reagent.
J Biol Chem
1951;
193
: 265–275.
37. Fueger PT, Shearer J, Bracy DP,
et al
. Control of muscle glucose uptake: Test of
the rate-limiting step paradigm in conscious, unrestrained mice.
J Physiol
2005;
562
: 925–935.
38. Alonso-Vale MI, Anhe GF, Borges-Silva CN,
et al
. Pinealectomy alters adipose
tissue adaptability to fasting in rats.
Metabolism
2004;
53
: 500–506.
39. Teodoro BG, Baraldi FG, Sampaio IH,
et al
. Melatonin prevents mitochondrial
dysfunction and insulin resistance in rat skeletal muscle.
J Pineal Res
2014;
57
:
155–167.
40. Cantwell EL, Cassone VM. Daily and circadian fluctuation in 2-deoxy [14C]-
glucose uptake in circadian and visual system structures of the chick brain:
Effects of exogenous melatonin.
Brain Res Bull
2002;
57
: 603–611.
41. Banerjee A, Udin S, Krishna A. Regulation of leptin synthesis in white adipose
tissue of the female fruit bat, cynopterus sphinx: role of melatonin with or
without insulin.
Exp Physiol
2011;
96
: 216–225.
42. Wang P, She M, He P,
et al
. Piromelatine decreases triglyceride accumulation in
insulin resistant 3T3-L1 adipocytes: Role of ATGL and HSL.
Biochimie
2013;
95
:
1650–1654.
43. Carroll R, Carley AN, Dyck JR, Severson DL. Metabolic effects of insulin on
cardiomyocytes from control and diabetic db/db mouse hearts.
Am J Physiol
Endocrinol Metab
2005;
288
: E900–E906.
44. Owino S, Contreras-Alcantara S, Baba K, Tosini G. Melatonin signaling controls
the daily rhythm in blood glucose levels independent of peripheral clocks.
PloS
One
2016;
11
: e0148214.
45. Mueckler M, Thorens B. The SLC2 (GLUT) family of membrane transporters.
Mol
Aspects Med
2013;
34
: 121–138.
46. Rios-Lugo MJ, Cano P, Jimenez-Ortega V,
et al
. Melatonin effect on plasma
adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and
high fat-fed rats.
J Pineal Res
2010;
49
: 342–348.
47. Zanquetta MM, Seraphim PM, Sumida DH, Cipolla-Neto J, Machado UF. Calorie
restriction reduces pinealectomy-induced insulin resistance by improving GLUT4
gene expression and its translocation to the plasma membrane.
J Pineal Res
2003;
35
: 141–148.
48. Faria JA, Kinote A, Ignacio-Souza LM,
et al
. Melatonin acts through MT1/MT2
receptors to activate hypothalamic AKT and suppress hepatic gluconeogenesis
in rats.
Am J Physiol Endocrinol Metab
2013;
15
: E230–242.
49. Montessuit C, Lerch R. Regulation and dysregulation of glucose transport in
cardiomyocytes.
Biochim Biophys Acta
2013;
1833
: 848–856.
50. Dominguez-Rodriguez A, Abreu-Gonzalez P, Arroyo-Ucar E, Reiter RJ. Decreased
level of melatonin in serum predicts left ventricular remodelling after acute
myocardial infarction.
J Pineal Res
2012;
53
: 319–323.
51. Dominguez-Rodriguez A, Abreu-Gonzalez P, Garcia MJ, Sanchez J, Marrero F, de
Armas-Trujillo D. Decreased nocturnal melatonin levels during acute myocardial
infarction.
J Pineal Res
2002;
33
: 248–252.
52. Fields AV, Patterson B, Karnik AA, Shannon RP. Glucagon-like peptide-1 and
myocardial protection: More than glycemic control.
Clin Cardiol
2009;
32
: 236–
243.
DYNA INDAPAMIDE SR.
Each tablet contains 1,5 mg indapamide. S3 A42/7.1/0790. NAM NS2 12/7.1/0138.
For full prescribing information, refer to the package insert approved by the Medicines Control Council,
25 November 2011.
1)
Weidmann P. Metabolic profile of indapamide sustained-release in patients with
hypertension. Drug Safety 2001;24(15):1155-1165.
2)
Database of Medicine Prices (10 March 2017).
Department of Health website.
http://www.mpr.gov.za- Accessed on 10 March 2017.
DINE279/03/2017.
only generic
1,5 mg
sustained release
formulation
R36
,70
2
CUSTOMER CARE LINE
0860 PHARMA (742 762) / +27 21 707 7000
www.pharmadynamics.co.zaDaniel Binette – Managing
Director, Lilly South Africa